From I-4 or I-4 Express Heading West:

Take exit 84A for Colonial Drive toward US-17/US-92/FL-50. Use the left lane to turn left onto West Ivanhoe Boulevard. Continue onto Legion Place. In one block, use the left lane to merge onto North Orange Avenue. In two blocks, turn left. In 180 feet, the entrance to One Orlando Centre will be on the right.

From I-4 or I-4 Express Heading East:

Take exit 84B (US-92 East/Highway 17 North/West Colonial Drive and North Magnolia Avenue) from I-4 East. Merge onto North Garland Avenue. Turn right onto US-92 East/Highway 17 North/West Colonial Drive. In 3 blocks, turn left onto North Magnolia Avenue. Turn left at your next opportunity, and the entrance to One Orlando Centre will be on the left.

From the Airport:

Take FL-408 West toward downtown Orlando. In about 4 miles, use the right lane to take Exit 10A for I-4 East toward Daytona Beach (via Florida's Turnpike -- toll road). Exit onto the I-4 E/Daytona Beach ramp. Take I-4 East to Exit 84B for Colonial Drive West/FL-50 West. Merge onto North Garland Avenue; then turn right onto US-92 East/Highway 17 North/West Colonial Drive. Turn left onto North Magnolia Avenue. In 3 blocks, just beyond Park Lake Street, make two lefts to enter One Orlando Centre, on the left.